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KMID : 1189420210340040049
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2021 Volume.34 No. 4 p.49 ~ p.70
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Systematic Review on Presbycusis Treated by Herbal Medicine Focusing on Kidney Deficiency
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Lim Hui-Yeong
Jin Han-Sol
Ko Woo-Shin
Yoon Hwa-Jung
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Abstract
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Objectives : This study was conducted to approve the effectiveness and safety of herbal medicine on presbycusis with kidney deficiency.
Methods : We searched randomized controlled trials(RCTs) on presbycusis patients diagnosed with kidney deficiency through 10 electronic databases from the start to Sep 7, 2021. Study collection and data extraction, and evaluation of risk of bias were conducted by two independent collaborator. The evaluation of the risk of bias in included RCTs was carried out by using Cochrane risk-of-bias tool. And the data synthesis was conducted by using Review Manager(RevMan, ver.5.4).
Results : 1. The treatment group which used herbal medicine(HM) alone was more effective than the control group which used only western medicine(WM) on effective rate of hearing loss. 2. In 3 studies comparing the HM-WM combination treatment group with the control groups using the same WM treatment, the effective rate was statistically significantly higher in the HM-WM combination treatment group. 3. Of the 5 studies that reported adverse reactions, one study reported mild nausea and dizziness, but the difference between the HM treatment group and the WM control group was not statistically significant, and no side effects occurred in other 3 studies. 4. In studies comparing HM and WM, the HM treatment group improved hearing loss, whole blood viscosity, serum TNF-α, IL-1β, IL-6, and oxidative stress indicators better than the WM control group, and there was no significant difference. 5. In studies comparing the HM-WM treatment group with the WM control group, the severity of tinnitus, quality of life, and feelings of anxiety and depression were better in the treatment group than the control group.
Conclusions : This study shows that the herbal medicine can improve symptoms of presbycusis with kidney deficiency.
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KEYWORD
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Presbycusis, Age-related hearing loss, Herbal medicine, Kidney deficiency
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